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Treatment-resistant mood disorders

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Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of treatment-resistant mood disorders and reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and interested primary care physicians.

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Summary Note

Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. The assessment and management of refractory patients with mood disorders is a major clinical challenge for mental health providers. Part of the Oxford Psychiatry Library (OPL) series, this pocketbook provides a concise view of the current definitions, assessment and evidence-based management of treatment-resistant mood disorders and reviews novel therapeutic targets for mood disorders, which may enhance the therapeutic armamentarium of clinicians in the near future. The pocketbook serves as a useful guide for mental health practitioners, including psychiatrists, clinical psychologists, trainees, and interested primary care physicians.

Content Note

1. Treatment-resistant major depressive disorder: current definitions, epidemiology, and assessment -- 2. Treatment-resistant bipolar disorder: current definitions, epidemiology, and assessment -- 3. Determinants of treatment resistance: health systems and public policy implications -- 4. The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders -- 5. Predictors of treatment response in major depressive disorder -- 6. Predictors of treatment response in bipolar disorder: lessons from longitudinal studies -- 7. Evidence-based pharmacological approaches for treatment-resistant major depressive disorder -- 8. Evidence-based pharmacological approaches for treatment-resistant bipolar disorder -- 9. Psychosocial management of treatment resistant mood disorders: current evidence -- 10. Electroconvulsive therapy for treatment-resistant mood disorders: current evidence -- 11. Novel non-invasive brain stimulation approaches for treatment-resistant mood disorders -- 12. Vagus nerve stimulation and deep brain stimulation: implantable device-related neurostimulation for treatment-resistant mood disorders -- 13. Novel therapeutic targets for major depressive disorder -- 14. Novel therapeutic targets for bipolar disorder.