Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.

Intro -- Title -- Copyright -- Contents -- Chapter 1 Alzheimer's is a Multifactorial Disease -- 1.1 Introduction -- 1.2 Pathological Events -- 1.2.1 Amyloid Burden -- 1.2.2 Tau Toxicity -- 1.2.3 Metal Ion Toxicity -- 1.2.4 Oxidative Stress -- 1.2.5 Biomolecule Damage -- 1.2.6 Membrane Toxicity -- 1.2.7 Calcium Dyshomeostasis -- 1.2.8 Role of Cholesterol -- 1.2.9 Mitochondrial Dysfunction -- 1.2.10 Endoplasmic Reticulum Stress -- 1.2.11 Impairment in Telomerase Activity -- 1.2.12 Cholinergic Toxicity -- 1.2.13 Synaptic Dysfunction -- 1.2.14 Immune Outrage -- 1.2.15 Neurovascular Toxicity. 2.3.2 When Amyloid Plaque Dysfunctions Together With Tau Pathology That Results in Havoc -- 2.3.3 Other Cellular Mishaps That Converge in the Anomaly of Homeostasis -- 2.4 Genetics as a Promising Tool for Alzheimer's Disease -- References -- Chapter 3 Alzheimer's Disease Pathology: A Tau Perspective -- 3.1 Tau and Alzheimer's Disease -- 3.1.1 Alzheimer's Disease -- 3.2 Conclusions -- 3.3 Future Perspectives for Small Molecules As Tau Therapeutics -- References