Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research.

Description based upon print version of record. Chapter 6 Influence of DNA Structure on Lesion Formation and Repair: Role of Modelling and Simulations 105.

Intro -- Half Title -- Series Title -- Title -- Copyright -- Contents -- Preface -- Chapter 1 Photoinduced Processes in DNA: Basic Theoretical and Experimental Features 1 -- 1.1 Introduction -- 1.2 A Theoretical Basis -- 1.3 Notion of Spectrum in Photobiology -- 1.3.1 Emission Spectrum of the Light Source -- 1.3.2 Absorption Spectrum -- 1.3.3 Action Spectrum -- 1.4 A Basic Introduction to Pump-probe Spectroscopies -- 1.5 Analytical Tools for the Detection of DNA Damage -- 1.5.1 Antibody-based Assays -- 1.5.2 Electrophoresis-based Assays -- 1.5.3 Chromatography-based Assays. 1.6 Basic Biological Phenomena Associated with DNA Damage -- 1.6.1 From DNA Damage to Abnormal Proteins -- 1.6.2 Principle of DNA Repair -- Acknowledgements -- References -- Chapter 2 Photoinduced Dimerization in DNA: Singlet Excited State Reaction Paths 17 -- 2.1 Introduction -- 2.2 Pyrimidine Dimers -- 2.2.1 Mechanism of Thymine-Thymine Photodimerization -- 2.2.2 Cytosine-Thymine -- 2.3 Purine-Purine and Purine-Pyrimidine Dimers -- 2.4 Concluding Remarks -- Acknowledgements -- References -- Chapter 3 DNA Photoionization: From High to Low Energies 37 -- 3.1 Introduction 3.2 Energies and Quantum Yields -- 3.2.1 Direct High-energy Photoionization -- 3.2.2 Indirect Low-energy Photoionization -- 3.3 Nanosecond Flash Photolysis: Advantages and Limitations -- 3.4 Evolution of Ejected Electrons -- 3.5 Evolution of Purine Radicals -- 3.5.1 Deprotonation and Tautomerization -- 3.5.2 Radical Populations -- 3.5.3 Reaction Dynamics -- 3.6 Final Lesions -- Acknowledgements -- References -- Chapter 4 Triplet Channel Photochemistry in DNA 55 -- 4.1 Introduction -- 4.2 Formation of Nucleobase Triplet Excited State 4.2.1 Intrinsic Population of Nucleobase Triplet Excited State -- 4.2.2 Photosensitized Population of the Lowest Nucleobases Triplet Excited State -- 4.2.3 Triplet-Triplet Energy Transfer Within the Helix -- 4.3 Photoreactivity -- 4.3.1 Cyclobutane Pyrimidine Dimers Formation -- 4.3.2 Spore Photoproduct Formation -- 4.3.3 Formation of (6-4) Photoproduct -- 4.3.4 Reactivity from Upper Triplet Excited States -- 4.4 Conclusion -- References -- Chapter 5 Tracking Excited Electronic States in DNA From Formation to Deactivation 77 -- 5.1 Introduction 5.2 Excited States of DNA: Their Nature and Steady-state Spectra -- 5.2.1 Electronic Absorption Spectra and Lineshapes -- 5.2.2 Exciton Theory and Coupled Chromophores -- 5.3 Excited States of DNA: Dynamic Properties -- 5.3.1 Dynamics of Base Monomer Excited States -- 5.3.2 Dynamics of DNA Strand Excited States -- 5.3.3 Long-lived Intrastrand CT States -- 5.3.4 Formation and Decay of CT States -- 5.3.5 Excited-state Proton Transfer in Double Strands -- 5.3.6 Conformational Dynamics and Excited State Dynamics -- 5.4 Outlook -- References