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Origins: rise of the great American patent -- Ethical medicine in the republic of science -- Death of the taboo: sunshine in a bottle -- Thurman's army: the New Deal against monopoly -- Homesteading the endless frontier: patents, penicillin and superpower science -- The birth of big pharma and the ghost of reform -- The making of a monster -- Black pill, neoliberalism and the Chicago turn -- Bayh-Dole and the Reagan acceleration -- The most expensive drug ever sold: generics, AIDS and AZT -- The World Trade Organization: drug monopolies at the end of history -- COVID-19 an the battle over business as usual -- Pharma's best friend: Bill Gates and COVID-19 -- Crown jewels in a black box: trade secrets and lies.